Twenty-eight species of cetacean have been recorded from the ecoregion. Most of these are wide-ranging oceanic species. There are two resident groups of bottlenose dolphins (Tursiops truncatus) near the islands. Population trends for most cetacean species are not known, although it appears that the number of sperm whales (Physeter macrocephalus) using the ecoregion in summer (ca. 300 individuals) is stable.
The Mediterranean monk seal (Monarchus monarchus) was present in previous centuries, but nowadays only vagrant individuals occur.